PRELIMINARY EVALUATION OF EXTRACTS OF ALSTONIA-SCHOLARIS BARK FOR INVIVO ANTIMALARIAL ACTIVITY IN MICE

被引:40
|
作者
GANDHI, M [1 ]
VINAYAK, VK [1 ]
机构
[1] POSTGRAD INST MED EDUC & RES,DEPT EXPTL MED,CHANDIGARH 160012,INDIA
关键词
D O I
10.1016/0378-8741(90)90097-D
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The petroleum either extract and methanol extract of the bark of Alstonia scholaris were found to be devoid of antiamalarial activity in mice infected with Plasmodium berghei However, a dose-dependent improvement of conditions and delayed mortality amongst animals receiving methanol extract of A. scholaris was noticed. Studies with A. constricta and alstonine shall help resolve the antimalarial status of the bark in question. © 1990.
引用
收藏
页码:51 / 57
页数:7
相关论文
共 50 条
  • [31] In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
    Biruk, Hana
    Sentayehu, Biruk
    Alebachew, Yonatan
    Tamiru, Wondmagegn
    Ejigu, Abebe
    Assefa, Solomon
    BIOCHEMISTRY RESEARCH INTERNATIONAL, 2020, 2020
  • [32] Effect of Alstonia Boonei Stem Bark Extracts on the Activity of Liver Maker Enzymes in Rats Induced by Ccl4
    Okpashi, Victor E.
    Uroko, Robert, I
    Ogana, Joy
    Agbafor, A.
    Nwuke, C. P.
    BAGHDAD SCIENCE JOURNAL, 2022, 19 (05) : 1058 - 1065
  • [33] Evaluation of toxicity of Bilsaan stem bark extracts in Swiss Albino mice
    Alrumaihi, Faris
    INTERNATIONAL JOURNAL OF HEALTH SCIENCES-IJHS, 2019, 13 (05): : 31 - 36
  • [34] Ethanolic extracts of Tinospora cordifolia and Alstonia scholaris show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria
    Bonvicini, Francesca
    Mandrone, Manuela
    Antognoni, Fabiana
    Poli, Ferruccio
    Gentilomi, Giovanna Angela
    NATURAL PRODUCT RESEARCH, 2014, 28 (18) : 1438 - 1445
  • [35] Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium
    Pabón, A
    Lopera, T
    Carmona, J
    Blair, S
    PHARMAZIE, 2001, 56 (05): : 412 - 414
  • [36] Antimalarial Activity of Seed Extracts of Schinus molle Against Plasmodium berghei in Mice
    Mekuria, Abebe Basazn
    Geta, Mestayet
    Birru, Eshetie Melese
    Gelayee, Desalegn Asmelashe
    JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE, 2020, 26
  • [37] In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii
    Kikueta, C. M.
    Kambu, O. K.
    Mbenza, A. P.
    Mavinga, S. T.
    Mbamu, B. M.
    Cos, P.
    Maes, L.
    Apers, S.
    Pieters, L.
    Cimanga, R. K.
    JOURNAL OF ETHNOPHARMACOLOGY, 2013, 149 (02) : 438 - 442
  • [38] Phytotherapeutic Analysis of Chloroform-Based Fractions of Alstonia scholaris and Wrightia tinctoria Extracts Reveals Potent Anti-Psoriatic Activity: An In Vitro and In Vivo Study
    Ojha, Madhavi
    Manocha, Nilanshu
    Kumar, Vinod
    Karthikeyan, Ganeshan
    Toor, Devinder
    PHARMACEUTICALS, 2025, 18 (03)
  • [39] Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice
    Belay, Wubetu Yihunie
    Gurmu, Abyot Endale
    Wubneh, Zewdu Birhanu
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 2018
  • [40] Evaluation of the antimalarial activity of extracts of carob tree (Ceratonia siliqua L.)
    Custodio, L.
    Marques, L.
    Mayor, A.
    Alonso, P.
    Albericio, F.
    Romano, A.
    PLANTA MEDICA, 2008, 74 (09) : 950 - 951