INHIBITION OF HUMAN PLATELET ACTIVATION BY POLYMORPHONUCLEAR LEUKOCYTES

被引：20
|
作者：
SCHATTNER, MA
GEFFNER, JR
ISTURIZ, MA
LAZZARI, MA
机构：
[1] Instituto Investigaciones, Academia Nacional de Medicina, 1425 Buenos Aires
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 02期
关键词：
D O I：
10.1111/j.1476-5381.1990.tb12696.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The effect of unstimulated human polymorphonuclear leukocytes (PMNs) on platelet activation was examined. 2. Human platelet aggregation and adenosine 5'-triphosphate (ATP) release induced by collagen (1-2 μg ml-1); thrombin (0.01-0.02 u ml-1) or arachidonic acid (AA) (0.1-0.2 mM) were markedly inhibited when conducted in the presence of unstimulated PMNs. 3. Platelet inhibition induced by PMNs was dependent on the number of PMNs and on the incubation time of the mixed cell suspension. 4. Platelet inhibition was not reversed in time when PMNs were depleted from the mixed-cell suspension. 5. PMN-mediated platelet-inhibiton was not mediated by AA metabolites, oxygen reactive intermediates, nitric oxide or proteases. 6. The factor(s) accounting for the platelet inhibition mediated by PMNs are not yet characterized.
引用
收藏
页码：253 / 256
页数：4
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