CONFORMATIONAL PROPERTIES OF BENZODIOXAN DERIVATIVES WITH ALPHA-ADRENERGIC BLOCKING ACTIVITY

被引：0
|
作者：
BALSAMO, A
MACCHIA, B
MACCHIA, F
MARTINELLI, A
TOGNETTI, P
VERACINI, CA
机构：
[1] UNIV PISA, IST CHIM FARMACEUT, I-56100 PISA, ITALY
[2] UNIV PISA, IST CHIM ORGAN, I-56100 PISA, ITALY
[3] UNIV PISA, IST CHIM FIS, I-56100 PISA, ITALY
来源：
MOLECULAR PHARMACOLOGY | 1981年 / 20卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Benzodioxan derivatives active on the .alpha.-adrenergic receptor are considered. The half-chair equilibrium of the dioxane ring was studied by 1H-NMR spectroscopy for piperoxan X and quiloflex XII. The preferred conformation was also obtained by PCILO [perturbative configuration interaction using localized orbitals] calculations for X. The results were evaluated to obtain information on the mechanism of the .alpha.-adrenergic drug-receptor interaction.
引用
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页码：371 / 376
页数：6
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