CLASS-I AND CLASS-II HLA TYPING AFTER A 10 GY-4 HOUR THERAPEUTIC TOTAL-BODY IRRADIATION

被引：2
|
作者：
COSSET, JM
RAFFOUX, C
CHAILLET, MP
SOCIE, G
BRIOT, E
FOLLEZOU, JY
GRIMAUD, E
DUBRAY, B
GIRINSKI, T
机构：
[1] HOP ST LOUIS, FRANCE TRANSPLANT, F-75010 PARIS, FRANCE
[2] DRET, CEB, DPN, F-94111 ARCUEIL, FRANCE
[3] HOP ST LOUIS, CEA, DSV, BIOL CELLULES SOUCHES, F-75010 PARIS, FRANCE
[4] INST GUSTAVE ROUSSY, F-94805 VILLEJUIF, FRANCE
[5] INSERM, U247, F-94800 VILLEJUIF, FRANCE
[6] HOP LA PITIE SALPETRIERE, F-75651 PARIS 13, FRANCE
来源：
HEALTH PHYSICS | 1993年 / 64卷 / 06期
关键词：
WHOLE BODY IRRADIATION; BONE MARROW; BLOOD; DOSE ASSESSMENT;
D O I：
10.1097/00004032-199306000-00014
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Class I and II HLA typing was investigated before and at various intervals after a 10 Gy total body irradiation delivered over 4 h, prior to allogeneic bone marrow graft for various hematological malignancies, in 14 patients. A reliable class I HLA typing appeared to be possible in almost all cases 6-8 hours after the start of irradiation but was only possible in 5 patients after 24 h. Preliminary results with class II antigens might suggest a more marked ''fragility'' of this antigen class after irradiation. These results encourage the drawing of blood samples for HLA grouping as soon as possible after accidental whole-body irradiation.
引用
收藏
页码：667 / 670
页数：4
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