REGULATION OF CA-2+ FLUXES IN RAT-LIVER MITOCHONDRIA BY CA-2+ - EFFECTS ON CA-2+ DISTRIBUTION

被引：13

作者：

SARIS, NEL ^{[1
]}

KRONER, H ^{[1
]}

机构：

[1] UNIV DUSSELDORF, DEPT PHYSIOL CHEM, W-4000 DUSSELDORF 1, GERMANY

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1990年 / 22卷 / 01期

关键词：

calcium efflux; Calcium uniporter; liver mitochondria; membrane potential; regulation of uniporter;

D O I：

10.1007/BF00762847

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Rat liver mitochondria are able to temporarily lower the steady-state concentration of external Ca2+ after having accumulated a pulse of added Ca2+. This has been attributed to inhibition of a putative Δψ-modulated efflux pathway [Bernardi, P. (1984)Biochim. Biophys. Acta766, 277-282]. On the other hand, the rebounding could be due to stimulation of the uniporter by Ca2+ [Kröner, H. (1987)Biol. Chem. Hoppe-Seyler369, 149-155]. By measuring unidirectional Ca2+ fluxes, it was found that the uniporter was stimulated during the rebounding peak both under Bernardi's and Kröner's conditions, while no effects on the efflux could be demonstrated. The rate of unidirectional efflux of Ca2+ was not affected by inhibition of the uniporter. It appears likely that the rebounding is due to stimulation of the uniporter rather than inhibition of efflux. © 1990 Plenum Publishing Corporation.

引用

页码：81 / 90

页数：10

共 50 条

[41] INTERACTION BETWEEN CA-2+ AND CAMP IN THE HORMONAL-CONTROL OF HEPATOCYTE CA-2+ FLUXES
BLACKMORE, PF
MORGAN, NG
EXTON, JH
FEDERATION PROCEEDINGS, 1983, 42 (07) : 1848 - 1848
[42] EFFECTS OF INTRACELLULAR ACIDOSIS ON [CA-2+]I TRANSIENTS, TRANSSARCOLEMMAL CA-2+ FLUXES, AND CONTRACTION IN VENTRICULAR MYOCYTES
KOHMOTO, O
SPITZER, KW
MOVSESIAN, MA
BARRY, WH
CIRCULATION RESEARCH, 1990, 66 (03) : 622 - 632
[43] PHARMACOLOGICAL DISSECTION OF CA-2+ CHANNELS IN THE RAT AORTA BY CA-2+ ENTRY MODULATORS
RICO, I
ALONSO, MJ
SALAICES, M
MARIN, J
PHARMACOLOGY, 1990, 40 (06) : 330 - 342
[44] HIGH [CA-2+] IN THE CYTOSOL DOES NOT ABOLISH CA-2+ INDUCED CA-2+ RELEASE ALTHOUGH IT INACTIVATES SARCOLEMMAL CA-2+ CURRENT IN CANINE VENTRICULAR MYOCYTES
SZABO, B
BANYASZ, T
FUGATE, R
RAJAGOPALAN, C
LAZZARA, R
BIOPHYSICAL JOURNAL, 1993, 64 (02) : A206 - A206
[45] THE MECHANISM OF THE DECLINE IN RAT PROXIMAL TUBULE CA-2+ CAUSED BY CA-2+ DEPLETION
MANN, C
ROTHROCK, JK
BHATI, V
DOMINGUEZ, JH
CLINICAL RESEARCH, 1990, 38 (02): : A575 - A575
[46] CYTOTOXIC HYPERTHERMIA AND CA-2+ HOMEOSTASIS - THE EFFECT OF HEAT ON CA-2+ UPTAKE BY NONMITOCHONDRIAL INTRACELLULAR CA-2+ STORES
MIKKELSEN, RB
STEDMAN, T
RADIATION RESEARCH, 1990, 123 (01) : 82 - 86
[47] ASPECTS OF THE ENERGETICS AND REGULATION OF CA-2+ FLUX IN MITOCHONDRIA
VERCESI, AE
PEREIRADASILVA, L
MARTINS, IS
CARNIERI, EGS
BERNARDES, CF
VALLE, VGR
FAGIAN, MM
FERRAZ, VL
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1986, 19 (4-5) : A609 - A609
[48] IMAGING OF CYTOSOLIC CA-2+ TRANSIENTS ARISING FROM CA-2+ STORES AND CA-2+ CHANNELS IN SYMPATHETIC NEURONS
LIPSCOMBE, D
MADISON, DV
POENIE, M
REUTER, H
TSIEN, RW
TSIEN, RY
NEURON, 1988, 1 (05) : 355 - 365
[49] CA-2+ BINDING-SITES IN PLASMA-MEMBRANES OF RAT-LIVER AND HEPATOMA-CELLS, AND EFFECT OF CONCANAVALIN A ON THE CA-2+ BINDING-SITES AND CELLULAR UPTAKE OF CA-2+
YAMAGAMI, K
TERAYAMA, H
BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 558 (02) : 199 - 213
[50] TRANSPORT OF CA-2+ AND MN-2+ BY MITOCHONDRIA FROM RAT-LIVER, HEART AND BRAIN
KONJI, V
MONTAG, A
SANDRI, G
NORDENBRAND, K
ERNSTER, L
BIOCHIMIE, 1985, 67 (12) : 1241 - 1250

← 1 2 3 4 5 →