INTERACTION BETWEEN AN ACIDIC ACTIVATOR AND TRANSCRIPTION FACTOR-TFIIB IS REQUIRED FOR TRANSCRIPTIONAL ACTIVATION

被引：207

作者：

ROBERTS, SGE ^{[1
]}

HA, I ^{[1
]}

MALDONADO, E ^{[1
]}

REINBERG, D ^{[1
]}

GREEN, MR ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT BIOCHEM,PISCATAWAY,NJ 08854

来源：

NATURE | 1993年 / 363卷 / 6431期

关键词：

D O I：

10.1038/363741a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HOW eukaryotic promoter-specific activator proteins (activators) stimulate transcription is a central question. We have previously shown that an acidic activator can directly interact with the general transcription factor TFIIB and increase its stable assembly into a preinitiation complex1,2. We have proposed that this increase in TFIIB assembly is at least part of the mechanism by which an acidic activator functions1,2. A prediction of this hypothesis is that a TFIIB mutant unable to interact with an acidic activator could not support activated transcription, and here we present experiments that verify this prediction. In conjunction with previous studies, our results argue that interaction between an acidic activator and TFIIB is necessary for transcriptional activation.

引用

页码：741 / 744

页数：4

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