INCREASING THE OPTICAL-ROTATION OF L-CARBIDOPA BY REACTION WITH DICARBONYL-COMPOUNDS

被引：3

作者：

NEAU, SH

CHAFETZ, L

CHOW, MY

机构：

[1] Center for Pharmaceutical Technology, University of Missouri-Kansas City. School of Pharmacy, Kansas City

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 82卷 / 1-2期

关键词：

L-CARBIDOPA; OPTICAL ROTATION; PYRAZOLE FORMATION;

D O I：

10.1016/0378-5173(92)90084-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To enhance optical rotation, the hydrazino moiety of L-carbidopa was derivatized to a pyrazole ring by reaction with a beta-dicarbonyl compound, 2,4-pentanedione, 1,1,1-trifluoro-2,4-pentanedione or malondialdehyde. Reaction with 2,4-pentanedione produced a product with an increased specific rotation in a derivatization completed in 20 min.

引用

页码：151 / 152

页数：2

共 28 条

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