INCREASING THE OPTICAL-ROTATION OF L-CARBIDOPA BY REACTION WITH DICARBONYL-COMPOUNDS

被引：3
|
作者：
NEAU, SH
CHAFETZ, L
CHOW, MY
机构：
[1] Center for Pharmaceutical Technology, University of Missouri-Kansas City. School of Pharmacy, Kansas City
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 82卷 / 1-2期
关键词：
L-CARBIDOPA; OPTICAL ROTATION; PYRAZOLE FORMATION;
D O I：
10.1016/0378-5173(92)90084-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To enhance optical rotation, the hydrazino moiety of L-carbidopa was derivatized to a pyrazole ring by reaction with a beta-dicarbonyl compound, 2,4-pentanedione, 1,1,1-trifluoro-2,4-pentanedione or malondialdehyde. Reaction with 2,4-pentanedione produced a product with an increased specific rotation in a derivatization completed in 20 min.
引用
收藏
页码：151 / 152
页数：2
相关论文
共 28 条
123