EFFECT OF SOMATOSTATIN AND ITS ANALOG ON PROLIFERATION OF HUMAN EPIDERMOID CARCINOMA-CELLS INVITRO

被引：15
|
作者：
KAMIYA, Y
OHMURA, E
ARAI, M
FUJII, T
HAYAKAWA, F
ITO, J
KAWAGUCHI, M
TSUSHIMA, T
SAKUMA, N
机构：
[1] TOKYO WOMENS MED COLL,DEPT INTERNAL MED 2,SHINJUKU KU,TOKYO 110,JAPAN
[2] RES INST GROWTH SCI,SHINJUKU KU,TOKYO 110,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 01期
关键词：
D O I：
10.1006/bbrc.1993.1217
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Somatostatin (SS) and its analogue inhibit the growth of some human tumors in vivo. Surprisingly, we found that SS-14 and its analogue (SMS 201-995) exhibited unexpected proliferative effects on two lines of cells, A431 and KB human epidermoid carcinoma cells, in vitro. The level of intracellular cyclic AMP, an important second messenger that controls the growth of A431 cells, was unaffected in A431 cells by either SS14 or SMS 201-995. In contrast, SS-14 (20 nM) and SMS 201-995 (10 nM) reduced the level of intracellular inositol 1,4,5-trisphosphate rapidly but transiently. © 1993 Academic Press.
引用
收藏
页码：302 / 307
页数：6
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