INHIBITION BY GINSENG TOTAL SAPONIN OF THE DEVELOPMENT OF MORPHINE REVERSE TOLERANCE AND DOPAMINE-RECEPTOR SUPERSENSITIVITY IN MICE

被引：31

作者：

KIM, HS

KANG, JG

OH, KW

机构：

来源：

GENERAL PHARMACOLOGY | 1995年 / 26卷 / 05期

关键词：

GINSENG TOTAL SAPONIN (GTS); REVERSE TOLERANCE; MORPHINE; SUPERSENSITIVITY;

D O I：

10.1016/0306-3623(94)00267-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Ginseng total saponin (GTS), 200 mg/kg i.p. 3 hr prior. to morphine, inhibited the development of reverse tolerance to the ambulatory-accelerating effect of morphine. 2. GTS, 200 mg/kg, also prevented the development of dopamine receptor supersensitivity induced by the chronic administration of morphine, 10 mg/kg a day for 7 days. 3. These results suggest that GTS may be useful for the prevention and therapy of the adverse action of morphine.

引用

页码：1071 / 1076

页数：6

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