MECHANISM OF CALCIUM IONOPHORE AND PHORBOL ESTER-INDUCED T-CELL ACTIVATION - ACCESSORY CELL REQUIREMENT FOR T-CELL ACTIVATION

被引:14
|
作者
HASHIMOTO, S [1 ]
TAKAHASHI, Y [1 ]
TOMITA, Y [1 ]
HAYAMA, T [1 ]
SAWADA, S [1 ]
HORIE, T [1 ]
MCCOMBS, CC [1 ]
MICHALSKI, JP [1 ]
机构
[1] LOUISIANA STATE UNIV,MED CTR,DEPT MED,NEW ORLEANS,LA 70112
关键词
D O I
10.1111/j.1365-3083.1991.tb01787.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We examined the role of monocytes in T-cell activation induced by phorbol myristate acetate (PMA) and calcium ionophore ionomycin. Depletion of monocytes from peripheral blood mononuclear cells (PBMC) was associated with the loss of interleukin-2 (IL-2) production, IL-2 receptor (IL-2R) expression and proliferation, in response to either PMA or ionomycin. Addition of monocytes to highly purified T cells resulted in the complete reconstitution of IL-2 production, IL-2R expression and proliferation by PMA-stimulated lymphocytes. Exogenous IL-2, but not interleukin-1 (IL-1), could reconstitute the T-cell responsiveness. Addition of monocytes to highly purified T cells stimulated with ionomycin resulted in partial reconstitution of IL-2 production, IL-2R expression and proliferation. Similarly, the addition of exogenous IL-2 to ionomycin-stimulated T cells only partially reconstituted the response compared with PBMC. These results suggest that monocyte-T-cell interactions contribute to IL-2 production and IL-2R expression and are crucial events for PMA-induced T-cell proliferation. With ionomycin, monocytes play a role, in part, in inducing IL-2 production, IL-2R expression and proliferation. However, IL-2 is not sufficient signal to induce T-cell proliferative response to ionomycin, suggesting that an IL-2-independent mechanism may exist in ionomycin-induced T-cell proliferation.
引用
收藏
页码:393 / 403
页数:11
相关论文
共 50 条
  • [31] T-cell activation blocker
    Nature Biotechnology, 1996, 14 (04):
  • [32] T-CELL RECEPTOR AND T-CELL ACTIVATION PROFILES IN GVHD IN MAN
    QUARATINO, S
    KAHAN, M
    CAPPONI, D
    POLCHI, P
    LONDEI, M
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 382 - 382
  • [33] T-CELL ACTIVATION BY SUPERANTIGENS
    WEBB, SR
    GASCOIGNE, NRJ
    CURRENT OPINION IN IMMUNOLOGY, 1994, 6 (03) : 467 - 475
  • [34] JNK is required for effector T-cell function but not for T-cell activation
    Chen Dong
    Derek D. Yang
    Cathy Tournier
    Alan J. Whitmarsh
    Jie Xu
    Roger J. Davis
    Richard A. Flavell
    Nature, 2000, 405 : 91 - 94
  • [35] REGULATION OF T-CELL ACTIVATION - DIFFERENCES AMONG T-CELL SUBSETS
    GAJEWSKI, TF
    SCHELL, SR
    NAU, G
    FITCH, FW
    IMMUNOLOGICAL REVIEWS, 1989, 111 : 79 - 110
  • [36] INJURY INDUCED BLOCK IN T-CELL ACTIVATION
    GADD, MA
    HANSBROUGH, JF
    OZKAN, AN
    HOYT, DB
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1988, 28 (07): : 1086 - 1086
  • [37] Plasma membrane calcium channels and T-cell activation
    不详
    IMMUNOBIOLOGY, 2004, 209 (4-6) : 424 - 424
  • [38] CYTOKINE REQUIREMENT FOR ALLOGENEIC T-CELL ACTIVATION IS DETERMINED BY THE ANTIGEN PRESENTING CELL
    PARIS, L
    BRADLEY, B
    LAFFERTY, KJ
    CLINICAL RESEARCH, 1989, 37 (01): : A156 - A156
  • [39] A REQUIREMENT FOR THE CD5-ANTIGEN IN T-CELL ACTIVATION
    MCATEER, MJ
    LAGARDE, AC
    GEORGIOU, HM
    BELLGRAU, D
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (07) : 1111 - 1117
  • [40] DISTINCTION BETWEEN ANTIGEN RECEPTOR AND IL-2 RECEPTOR TRIGGERING EVENTS IN THE ACTIVATION OF ALLOREACTIVE T-CELL CLONES WITH CALCIUM IONOPHORE AND PHORBOL ESTER
    ALBERT, F
    HUA, C
    TRUNEH, A
    PIERRES, M
    SCHMITTVERHULST, AM
    JOURNAL OF IMMUNOLOGY, 1985, 134 (06): : 3649 - 3655