ASP-56, A NEW ACTIN SEQUESTERING PROTEIN FROM PIG PLATELETS WITH HOMOLOGY TO CAP, AN ADENYLATE CYCLASE-ASSOCIATED PROTEIN FROM YEAST

被引：70
|
作者：
GIESELMANN, R
MANN, K
机构：
[1] TECH UNIV MUNICH,DEPT BIOPHYS,W-8046 GARCHING,GERMANY
[2] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY
来源：
FEBS LETTERS | 1992年 / 298卷 / 2-3期
关键词：
ACTIN-SEQUESTERING PROTEIN; ACTIN; ADENYLATE CYCLASE-ASSOCIATED PROTEIN;
D O I：
10.1016/0014-5793(92)80043-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new 56 kDa actin-binding protein (ASP-56) was isolated from pig platelet lysate. In falling ball viscosimetry it caused a reduction in viscosity that could be attributed to a decrease in the concentration of polymeric actin. Fluorescence measurements with NBD-labelled actin showed reduction of polymeric actin, too. These results could be explained by sequestering of actin in a non-polymerizable 1:1 ASP-56/actin complex. Sequencing of about 20 tryptic peptides of ASP-56 and comparison with known sequences revealed about 60% homology to the adenylate cyclase-associated protein (CAP) from yeast.
引用
收藏
页码：149 / 153
页数：5
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