ANTIBODY TO PEPTIDES OF HUMAN MYELIN BASIC-PROTEIN IN POST-RABIES VACCINE ENCEPHALOMYELITIS SERA

被引：15
|
作者：
UBOL, S
HEMACHUDHA, T
WHITAKER, JN
GRIFFIN, DE
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,MEYER BLDG,ROOM 6-181,600 N WOLFE ST,BALTIMORE,MD 21205
[2] CHULALONGKORN UNIV,DEPT NEUROL,BANGKOK,THAILAND
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205
[4] UNIV ALABAMA,DEPT NEUROL,BIRMINGHAM,AL 35294
[5] VET ADM MED CTR,BIRMINGHAM,AL 35233
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 26卷 / 02期
关键词：
Demyelinating disease; Myelin basic protein; Rabies vaccine;
D O I：
10.1016/0165-5728(90)90081-W
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Development of neurologic complications after Semple rabies vaccine is closely linked to deveopment of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassays in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89,and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic comlication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 42-170. © 1990.
引用
收藏
页码：107 / 111
页数：5
相关论文
共 50 条
12345