Crystal structure of 1,7,8,9-tetrachloro-4-(2-fluorobenzyl)-10,10-dimethoxy-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione

被引：1

作者：

Zhong, Jia-liang ^{[1
]}

Hou, Jia-wei ^{[1
]}

Liu, Li-hong ^{[2
]}

Liu, He ^{[2
]}

机构：

[1] Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China

[2] Capital Med Univ, Beijing Chao Yang Hosp, Beijing 100020, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2015年 / 71卷

关键词：

crystal structure; biochemical activity; tricyclo[5,2,1,0(2,6)]dec-8-ene-3,5-dione; hydrogen bonding; C-H center dot center dot center dot F interaction;

D O I：

10.1107/S2056989014026279

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound, C17H12Cl4FNO4, the configuration of the cycloalkene skeleton is endo, cis. The benzene ring is twisted by 71.01 (11)degrees from the attached pyrrolidine ring. In the crystal, one of the methine groups of the fused-ring system forms a weak C-H center dot center dot center dot O hydrogen bond. The other methine groups participates in a C-H center dot center dot center dot F interaction to the same adjacent molecule. Together, these generate [010] chains.

引用

页码：O32 / +

页数：9

共 50 条

[21] 6-(4-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione)
Gooden, David M.
MOLBANK, 2009, (04)
[22] Synthesis and preliminary studies of biological activity of amino derivatives of 4-azatricyclo-[5.2.1.02,6]dec-8-ene-3,5-dione with silicon in the structure
Napiorkowska, Mariola
Cieslak, Marcin
Kazmierczak-Baranska, Julia
Krolewska, Karolina
Czapla, Aleksandra
Kuran, Bozena
HETEROCYCLIC COMMUNICATIONS, 2015, 21 (01) : 19 - 24
[23] Reactions of 4-amino-4-azatricyclo[5.2.1.02,6-endo]dec-8-ene-3,5-dione with dicarboxylic acid anhydrides
L. I. Kas’yan
I. N. Tarabara
Ya. S. Bondarenko
L. K. Svyatenko
A. V. Bondarenko
Russian Journal of Organic Chemistry, 2007, 43 : 1014 - 1026
[24] SYNTHESIS, STRUCTURE AND PHARMACOLOGICAL EVALUATION OF 1-(1H-PYRROL-1-YLMETHYL)-4-AZATRICYCLO[5.2.1.02.6] DEC-8-ENE-3,5-DIONE
Pakosinska-Parys, Magdalena
Zimniak, Andrzej
Chodkowska, Anna
Jagiello-Wojtowicz, Ewa
Glowala, Marek
Struga, Marta
ACTA POLONIAE PHARMACEUTICA, 2016, 73 (04): : 931 - 936
[25] 4-Hydroxy-1-methyl-7-(propan-2-yl)-4-azatricyclo [5.2.2.0(2,6)]undec-8-ene-3,5-dione
Szulczyk, Daniel
Struga, Marta
MOLBANK, 2012, (03)
[26] Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
Jerzy Kossakowski
Anna Bielenica
Marta Struga
Anna E. Koziol
Medicinal Chemistry Research, 2008, 17 : 507 - 514
[27] SYNTHESIS OF AMINO DERIVATIVES OF 10-(DIPHENYLMETHYLENE)-4-AZATRICYCLO[5.2.1.02.6]DEC-8-ENE-3,5-DIONE AS POTENTIAL PSYCHOTROPIC AND/OR ANTI HIV AGENTS
Kossakowski, Jerzy
Wojciechowska, Anna
Koziol, Anna E.
ACTA POLONIAE PHARMACEUTICA, 2006, 63 (04): : 261 - 264
[28] Spectroscopic (FT-IR, FT-Raman), first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of 1,7,8,9-tetrachloro-10, 10-dimethoxy-4-[3-(4-phenylpiperazin-l-yl)propyl]-4-azatricyclo [5.2.1.02,6]dec-8-ene-3,5-dione by density functional methods
Renjith, R.
Mary, Y. Sheena
Panicker, C. Yohannan
Varghese, Hema Tresa
Pakosinska-Parys, Magdalena
Van Alsenoy, C.
Manojkumar, T. K.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 124 : 500 - 513
[29] Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
Kossakowski, Jerzy
Bielenica, Anna
Struga, Marta
Koziol, Anna E.
MEDICINAL CHEMISTRY RESEARCH, 2008, 17 (08) : 507 - 514
[30] 2-(3,5-Dioxo-4-azatricyclo[5.2.1.0(2,6)]-dec-8-en-4-yl)acetic acid
Akkurt, Mehmet
Jarrahpour, Aliasghar
Shirvani, Pouria
Tahir, Muhammad Nawaz
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O1404 - +

← 1 2 3 4 5 →