PROPHYLACTIC INHALATION OF AMPHOTERICIN-B IN INVASIVE PULMONARY ASPERGILLOSIS - DISTRIBUTION STUDY

被引：0
|
作者：
BARZEN, G
BEYER, J
FARSHIDFAR, G
KRAMP, W
RICHTER, W
FELIX, R
机构：
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,MED KLIN & POLIKLIN,W-1000 BERLIN 65,GERMANY
[2] FREE UNIV BERLIN,INST DIAGNOST FORSCH,W-1000 BERLIN 33,GERMANY
来源：
NUKLEARMEDIZIN | 1993年 / 32卷 / 02期
关键词：
INVASIVE PULMONARY ASPERGILLOSIS; AMPHOTHERICIN-B; INHALATION;
D O I：
暂无
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Invasive pulmonary aspergillosis (IPA) during periods of immunosuppression or prolonged neutropenia is a serious condition with high mortality. Prophylaxis is unsatisfactory because of the low effectiveness of systemic administration of amphotericin B (AMB) and because of its side effects. Prophylactic inhalation of AMB by means of a nebulizing system may be able to reduce the incidence of IPA. Therefore, we studied the distribution of nebulized Tc-99m-labeled AMB and estimated its particle size. AMB is homogenously distributed in the lung and partly deposited in the terminal respiratory unit; it remains there with a half-life of at least 14 h. Therefore, prophylaxis of IPA with AMB nebulized as described can be recommended.
引用
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页码：82 / 86
页数：5
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