PEPTIC-ULCER PATHOPHYSIOLOGY

被引：47
|
作者：
MERTZ, HR
WALSH, JH
机构：
[1] VET ADM WADSWORTH MED CTR, CTR ULCER RES & EDUC, BLDG 115, ROOM 115, LOS ANGELES, CA 90073 USA
[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, DIV GASTROENTEROL, LOS ANGELES, CA 90024 USA
[3] UNIV CALIF LOS ANGELES, MED CTR, DIV GASTROENTEROL, LOS ANGELES, CA 90024 USA
[4] UNIV CALIF LOS ANGELES, CTR DIGEST DIS, LOS ANGELES, CA 90024 USA
来源：
MEDICAL CLINICS OF NORTH AMERICA | 1991年 / 75卷 / 04期
关键词：
D O I：
10.1016/S0025-7125(16)30412-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pathophysiology of peptic ulcer disease has yet to be completely elucidated. This article reviews in detail possible mechanisms involved in peptic ulcer development. Aggressive factors (acid and pepsin), defensive factors (mucus, bicarbonate secretion, blood flow, and cell junctions) and repair processes (growth factors and restitution) are discussed. Imbalances of these factors may be due to Helicobacter pylori, nonsteroidal anti-inflammatory drugs, stress, smoking, or intrinsic defects.
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页码：799 / 814
页数：16
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