AGNOR AREA IN INTERPHASE NUCLEI OF HUMAN TUMORS CORRELATES WITH THE PROLIFERATIVE ACTIVITY EVALUATED BY BROMODEOXYURIDINE LABELING AND KI-67 IMMUNOSTAINING

被引：115

作者：

TRERE, D

FARABEGOLI, F

CANCELLIERI, A

CECCARELLI, C

EUSEBI, V

DERENZINI, M

机构：

[1] UNIV BOLOGNA,CTR PATOL CELLULARE,DIPARTIMENTO PATOL SPERIMENTALE,I-40126 BOLOGNA,ITALY

[2] UNIV BOLOGNA,IST ANAT & ISTOL PATOL,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF PATHOLOGY | 1991年 / 165卷 / 01期

关键词：

AGNORS; NUCLEOLUS; PROLIFERATION; TUMORS; DIAGNOSIS; PROGNOSIS;

D O I：

10.1002/path.1711650109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The area of silver-stained proteins associated with interphase nucleolar organizer regions (AgNORs) was compared with labelling data obtained by bromodeoxyuridine (BrdU) incorporation and Ki-67 immunostaining in 25 tumours of different origins and two non-neoplastic lesions of the thyroid. Our data demonstrate a highly significant correlation between the mean area occupied by the AgNOR proteins measured by an image processing system and the proliferative indices evaluated by BrdU labelling (r = 0.89, P < 0.001) and Ki-67 immunostaining (r = 0.86, P < 0.001). AgNOR protein area measurement is therefore proposed as a simple, inexpensive, and reliable method of evaluating the proliferative activity in routinely processed tumour samples.

引用

页码：53 / 59

页数：7

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