A TRIAL OF A GROUP-A PLUS GROUP-C MENINGOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE IN AFRICAN INFANTS

被引：123
|
作者：
TWUMASI, PA
KUMAH, S
LEACH, A
ODEMPSEY, TJD
CEESAY, SJ
TODD, J
BROOME, CV
CARLONE, GM
PAIS, LB
HOLDER, PK
PLIKAYTIS, BD
GREENWOOD, BM
机构：
[1] MRC LABS,BANJUL,GAMBIA
[2] CTR DIS CONTROL & PREVENT,ATLANTA,GA
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1093/infdis/171.3.632
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The safety and immunogenicity of a group A plus group C meningococcal polysaccharide-CRM(197) conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses of conjugate vaccine or with two doses of a meningococcal A plus C polysaccharide vaccine. The conjugate vaccine produced few systemic side effects, and local reactions were similar to those produced by the polysaccharide vaccine. Postvaccination group A meningococcal polysaccharide antibody levels, measured by ELISA, increased progressively after one, two, or three doses of conjugate vaccine. However, one dose of conjugate vaccine given at the age of 6 months induced a higher group C meningococcal antibody response than did two doses of conjugate vaccine given at 2 and 6 months. Two doses of conjugate vaccine induced higher levels of antibody than did two doses of polysaccharide vaccine. Thus, this new meningococcal conjugate vaccine proved to be safe and immunogenic.
引用
收藏
页码：632 / 638
页数：7
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