NEGATIVE FEEDBACK OF CORTICOSTERONE ON THE PITUITARY-ADRENAL AXIS IS MAINTAINED AFTER INHIBITION OF SEROTONIN SYNTHESIS WITH PARACHLOROPHENYLALANINE

被引：7

作者：

ARMARIO, A ^{[1
]}

MARTI, O ^{[1
]}

GAVALDA, A ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA, FAC CIENCIES, DEPT BIOL CELLULAR & FISIOL, E-08193 BARCELONA, SPAIN

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 06期

关键词：

PARA-CHLOROPHENYLALANINE; SEROTONIN; ACTH; CORTICOSTERONE; NEGATIVE FEEDBACK; NOISE STRESS;

D O I：

10.1016/0361-9230(92)90212-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of the serotonergic transmission on the negative feedback of corticosterone on the pituitary-adrenal (PA) axis was studied in adult male rats. Animals were given p-chlorophenylalaine (PCPA) and 24 h later were administered corticosterone, 2 h before being subjected to 20 min of noise stress. The main results were as follows: First. PCPA administration increased resting levels of both corticotropin (ACTH) and corticosterone but did not alter PA response to noise stress: second. ACTH response to stress was eliminated in rats given PCPA: third, corticosterone reduced ACTH levels in nonstressed rats only and this effect was maintained after PCPA administration. Taken together. the present results suggest a mediator role for serotonin in the noise-stress-induced PA hormone release but no role in the negative feedback of corticosterone on the PA axis.

引用

页码：915 / 918

页数：4

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