E-CADHERIN AS A TUMOR (INVASION) SUPPRESSOR GENE

被引：166
|
作者：
BIRCHMEIER, W
机构：
[1] Max-Delbrück-Center for Molecular Medicine, Berlin, 13125
来源：
BIOESSAYS | 1995年 / 17卷 / 02期
关键词：
D O I：
10.1002/bies.950170203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper((1)) reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
引用
收藏
页码：97 / 99
页数：3
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