INTERLEUKIN-8, A CHEMOTACTIC AND INFLAMMATORY CYTOKINE

被引：823
|
作者：
BAGGIOLINI, M
CLARKLEWIS, I
机构：
[1] UNIV BRITISH COLUMBIA,BIOMED RES CTR,VANCOUVER V6T 1W5,BC,CANADA
[2] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER V6T 1W5,BC,CANADA
来源：
FEBS LETTERS | 1992年 / 307卷 / 01期
关键词：
INTERLEUKIN-8; RECEPTOR; BIOLOGICAL FUNCTION; NEUTROPHIL ACTIVATION; PATHOPHYSIOLOGY;
D O I：
10.1016/0014-5793(92)80909-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil-activating cytokines similar to IL-8 in structure and function have been identified recently. IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local neutrophil accumulation.
引用
收藏
页码：97 / 101
页数：5
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