HUMAN LUPUS-TYPE INCLUSIONS IN UMBILICAL-CORD BLOOD MONONUCLEAR-CELLS

被引：7
|
作者：
RICH, SA
GIBBONS, WE
机构：
[1] Laboratory of Biophysics, Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany
来源：
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 09期
关键词：
D O I：
10.1002/art.1780330915
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mononuclear cells purified from umbilical cord blood activated oligoadenylate synthetase and formed human lupus‐type inclusions (LI) when cultured with the purified recombinant human leukocyte interferon, IFLrA. LI frequencies increased from 0% to a low of 0.75% and a high of 6.25% in 4‐day cultures with IFLrA (100 units/ml). These interferon‐induced responses in the mononuclear cells of neonates indicate that LI are solely an intrinsic product of normal cells, and not an exogenous virus or some other environmental agent. Copyright © 1990 American College of Rheumatology
引用
收藏
页码：1420 / 1425
页数：6
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