Analgesic Effect of Ethanol Extracted Leaves of Psidium guajava']java Leaves In Animal Models

The research was carried out to investigate the analgesic effects of ethanol extract of Psidium guajava leaves. In order to assess the analgesic effects by acetic acid induced writhing response model. Leaf extract were administered (2mg/kg bodyweight) and the obtained effects were compared with commercially available analgesic drug Diclofenac sodium (40mg/kg bodyweight), Distilled water (2ml/kg body weight) was used as control for the study. In analgesic bioassay, oral administration of the ethanol extract of leaves were significantly (p< 0.01) reduced the writhing response. The efficacy of leaves extract was almost 60% which is found comparable to the effect of standard analgesic drug Diclofenac sodium (75%). we recommended further research on this plant leaves for possible isolation and characterization of the various active chemical substances which has the toxic and medicinal values.