RELATIONSHIP BETWEEN ALPHA(1)-ANTITRYPSIN INACTIVATION AND TUMOR-NECROSIS-FACTOR-ALPHA CONCENTRATION IN THE SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：15
|
作者：
CHIDWICK, K [1 ]
WHICHELOW, CE [1 ]
ZHANG, Z [1 ]
FAIRBURN, K [1 ]
SACHS, JA [1 ]
BLAKE, DR [1 ]
WINYARD, PG [1 ]
机构：
[1] UNIV LONDON LONDON HOSP,COLL MED,BONE & JOINT RES UNIT,LONDON E1 2AD,ENGLAND
来源：
ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 12期
关键词：
D O I：
10.1002/art.1780371203
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To examine the relationship between alpha(1)-antitrypsin (alpha(1)AT) specific activity and tumor necrosis factor alpha(TNF alpha) concentration in synovial fluid from 48 patients with rheumatoid arthritis. Methods.The specific activity of alpha(1)AT was calculated from the measurement of alpha(1)AT concentration (by rocket immunoelectrophoresis) and elastase inhibitory capacity. TNF alpha was detected by enzyme-linked immunosorbent assay. Results. TNF alpha concentrations correlated with the extent of alpha(1)AT inactivation. Conclusion. Our findings are consistent with a role of elastase in TNF alpha release within the inflamed joint.
引用
收藏
页码：1723 / 1726
页数：4
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