PHARMACOLOGICAL ACTIVITY OF PYRROLE DERIVATIVES

To search for new physiologically active compounds, a series of NH-, N-vinyl-2-arylpyrroles and their derivatives were synthesized and screened for their biological activity. The compounds in question were found to have moderate analgesic and psychotropic actions and a low toxicity. The biological action of the pyrroles under studv depended of the nature of a substituent in the pyrrole ring. The highest effect was produced by 2-arylpyrroles, the highest psychotropic effect was displayed by 2-aryl-5-pyrrolecarboxylic acids and their sodium salts.