SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES

被引：0

作者：

BUDRIESI, R ^{[1
]}

RAMPA, A ^{[1
]}

BISI, A ^{[1
]}

FABBRI, G ^{[1
]}

CHIARINI, A ^{[1
]}

VALENTI, P ^{[1
]}

机构：

[1] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1995年 / 45-1卷 / 03期

关键词：

BRADYCARDIAC AGENTS; BENZAZEPINONES; PHARMACOLOGY; SYNTHESIS; CALCIUM ANTAGONISTS; 7,8-DIMETHOXY-3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO] PROPYL]-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE HYDROCHLORIDE; UL-FS; 49;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of some benzazepinone derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. For the compounds bearing well-known alpha-blocking fragments the antagonist potency at postsynaptic alpha-adrenoceptors was assessed. The new compounds were less effective as bradycardic agents and calcium antagonists but show remarkable negative inotropic activity.

引用

页码：234 / 239

页数：6

共 50 条

[41] NEW COMPOUNDS - SYNTHESIS OF SOME SULFAZOPYRIDINE DERIVATIVES FOR PHARMACOLOGICAL STUDY
ABOUELEN.HY
KHALIFA, M
ABOUZEID, YM
JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (10) : 1358 - &
[42] SYNTHESIS AND PHARMACOLOGICAL INVESTIGATIONS OF SOME CARBAMIC ACID-DERIVATIVES
KUKALENKO, SS
TSYBULEVSKY, AG
SARATIKOV, AS
GORSHKOVA, VK
VORONINA, GY
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (06): : 41 - 43
[43] Synthesis, pharmacological and biological screening of some novel pyrimidine derivatives
Bhat, K. Ishwar
Kumar, Abhishek
Nisar, Muhammed
Kumar, Pankaj
MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (07) : 3458 - 3467
[44] Synthesis, pharmacological and biological screening of some novel pyrimidine derivatives
K. Ishwar Bhat
Abhishek Kumar
Muhammed Nisar
Pankaj Kumar
Medicinal Chemistry Research, 2014, 23 : 3458 - 3467
[45] Synthesis and pharmacological investigations of some 4-hydroxycoumarin derivatives
Manolov, I
Danchev, ND
ARCHIV DER PHARMAZIE, 2003, 336 (02) : 83 - 94
[46] SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF SOME DERIVATIVES OF P-AMINOPHENYLETHANOLAMINE
TEOTINO, UM
FRIZ, LP
STEIS, G
DELLABELLA, D
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1963, 15 (01) : 26 - &
[47] Synthesis and pharmacological properties of some novel pyrazolidine and pyrazole derivatives
Parashar, Bharat
Jain, Abhilasha
Bharadwaj, Sudhir
Sharma, V. K.
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (08) : 1692 - 1699
[48] Synthesis and pharmacological studies on some phthalimidoxy substituted quinoline derivatives
Bhambi, Dinesh
Sain, Devendra K.
Salvi, Vijay K.
Sharma, Chirag
Talesara, G. L.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2009, 86 (10) : 1072 - 1078
[49] Microwave assisted synthesis, characterization, molecular docking and pharmacological activities of some new 2′-hydroxychalcone derivatives
Uddin, Mohammad Nasir
Knock, Md Nazmul Hassan
Uzzaman, Monir
Bhuiyan, M. Mosharef H.
Sanaullah, A. F. M.
Shumi, Wahhida
Amin, Hossain Md Sadrul
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1206
[50] Synthesis and pharmacological screening of some substituted benzothiazole derivatives of thioquinazolinone
Patel, HH
Khedekar, PB
Bhusari, KP
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 15 (03) : 217 - 220

← 1 2 3 4 5 →