SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION OF SOME BENZAZEPINONE DERIVATIVES

被引：0

作者：

BUDRIESI, R ^{[1
]}

RAMPA, A ^{[1
]}

BISI, A ^{[1
]}

FABBRI, G ^{[1
]}

CHIARINI, A ^{[1
]}

VALENTI, P ^{[1
]}

机构：

[1] UNIV BOLOGNA,DIPARTIMENTO SCI FARMACEUT,I-40126 BOLOGNA,ITALY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1995年 / 45-1卷 / 03期

关键词：

BRADYCARDIAC AGENTS; BENZAZEPINONES; PHARMACOLOGY; SYNTHESIS; CALCIUM ANTAGONISTS; 7,8-DIMETHOXY-3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO] PROPYL]-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE HYDROCHLORIDE; UL-FS; 49;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of some benzazepinone derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. For the compounds bearing well-known alpha-blocking fragments the antagonist potency at postsynaptic alpha-adrenoceptors was assessed. The new compounds were less effective as bradycardic agents and calcium antagonists but show remarkable negative inotropic activity.

引用

页码：234 / 239

页数：6

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