Tocilizumab efficacy in a patient with positive anti-CCP chronic Lyme arthritis

被引：1

作者：

Hirsch, Julianna ^{[1
]}

Rosner, Itzhak ^{[1
,2
]}

Rimar, Doron ^{[1
,2
]}

Kaly, Lisa ^{[1
,2
]}

Rozenbaum, Michael ^{[1
,2
]}

Boulman, Nina ^{[1
,2
]}

Slobodin, Gleb ^{[1
,3
]}

机构：

[1] Technion Israel Inst Technol, Dept Med, Haifa, Israel

[2] Bnai Zion Med Ctr, Dept Rheumatol, Haifa, Israel

[3] Bnai Zion Med Ctr, Dept Internal Med A, Haifa, Israel

来源：

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES | 2016年 / 8卷 / 04期

关键词：

Lyme arthritis; lyme disease; tocilizumab;

D O I：

10.4103/1947-2714.179960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. Case Report: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hydroxychloroquine and methotrexate. The patient responded partially to tumor necrosis factor (TNF)-alpha blockade by etanercept and, finally, entered long-term remission after his treatment was switched to tocilizumab. Conclusion: Off label treatment by biologic disease modifying antirheumatic drugs can be considered in selected patients with severe antibiotic-resistant Lyme arthritis.C.

引用

页码：194 / 196

页数：3

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