EFFECT OF WATER-INSOLUBLE POWDER ADDITION ON PHYSICAL-PROPERTIES OF GELATIN GEL

被引:7
|
作者
SAMURA, K
KATO, Y
MORITA, Y
KAWAMURA, M
KOYAMA, N
OSAWA, S
机构
[1] Department of OTC Drug and Paramedical Formulation, Eisai Co., Ltd., Honjyo, Saitama
关键词
D O I
10.3109/03639049309047202
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Water-insoluble powder is often dispersed in shells of commercial soft capsules for various reasons, but little reports have been published about the effect of powder addition on the physical properties of the gelatin gel. Glass powder, titanium oxide, calcium carbonate and gamma-orizanol were used as model of powder. Changes of Young modulus obtained from the tensile test showed that any powder addition to the gelatin sheet made the gelatin sheet hard not by the surface effect of powder but by the volumetric effect of it. In this test, any powders had no effect on the tensile strength of the gelatin sheet because there was little interaction between each powder and the gelatin gel in the break point. The limiting strain was decreased a little up to the specific amount of each powder and then beyond the specific amount that decreased steeply in the case of glass powder and gamma-orizanol. There might be a suitable range of the amount of powder for the gelatin sheet to keep the plastic flow similar to the gelatin sheet containing no powder. In this work, it was shown that the physical properties of the gelatin shell would be regulated by powder addition to the gelatin sheet.
引用
收藏
页码:2579 / 2594
页数:16
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