ACTIVATION OF A METABOTROPIC EXCITATORY AMINO-ACID RECEPTOR POTENTIATES A(2B)ADENOSINE RECEPTOR-STIMULATED CYCLIC-AMP ACCUMULATION

被引:28
|
作者
ALEXANDER, SPH
CURTIS, AR
HILL, SJ
KENDALL, DA
机构
[1] Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham
基金
英国惠康基金;
关键词
EXCITATORY AMINO ACID RECEPTOR; A2B ADENOSINE RECEPTOR; CYCLIC AMP; RECEPTOR CROSSTALK;
D O I
10.1016/0304-3940(92)90085-L
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Incubation of guinea-pig cerebral cortical slices with the excitatory amino acid agoniStS DL-a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) or N-methyl-D-aspartate (NMDA) failed to significantly alter either basal or 5'-N-ethylcarboxamidoadenosine- (NECA-)stimulated cAMP levels. Quisqualate, L-glutamate and DL-1-aminocyclopentane-trans-1,3-dicarboxylate (t-ACPD) were also without effect on basal levels of cAMP but increased NECA-stimulated levels of cAMP to approximately 1901-220 and 290% of control levels, respectively. Analysis of t-ACPD concentration-response data for the potentiation of NECA-stimulated cAMP elevations and the stimulation of phosphoinositide turnover gave EC50 values of 51 and 107 muM, respectively. The enhancing effect of t-ACPD on cAMP levels was maintained for up to 40 minutes as was the stimulation of phosphoinositide turnover. We conclude that the cAMP response to A2b adenosine receptor stimulation is augmented by the rigid glutamate analogue t-ACPD, possibly through the action of products of phosphoinositide turnover.
引用
收藏
页码:231 / 233
页数:3
相关论文
共 50 条
  • [21] IS CYCLIC-AMP INVOLVED IN EXCITATORY AMINO ACID-EVOKED ADENOSINE RELEASE FROM RAT CORTICAL SLICES
    CRAIG, CG
    TEMPLE, SD
    WHITE, TD
    EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1994, 269 (01): : 79 - 85
  • [22] EXCITATORY AMINO-ACID RECEPTOR-MEDIATED ACTIVATION OF SOLITARIAL DEGLUTITIVE LOCI
    HASHIM, MA
    BIEGER, D
    NEUROPHARMACOLOGY, 1989, 28 (09) : 913 - 921
  • [23] COLCHICINE POTENTIATES BETA-ADRENORECEPTOR-STIMULATED CYCLIC-AMP IN LYMPHOMA-CELLS BY AN ACTION DISTAL TO RECEPTOR
    INSEL, PA
    KENNEDY, MS
    NATURE, 1978, 273 (5662) : 471 - 473
  • [24] MECHANISM OF EXCITATORY AMINO ACID-INDUCED ACCUMULATION OF CYCLIC-AMP IN HIPPOCAMPAL SLICES - ROLE OF EXTRACELLULAR CHLORIDE
    BABA, A
    NISHIUCHI, Y
    UEMURA, A
    IWATA, H
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1988, 245 (01): : 299 - 304
  • [25] METABOTROPIC AND IONOTROPIC EXCITATORY AMINO-ACID RECEPTOR AGONISTS INDUCE DIFFERENT BEHAVIORAL-EFFECTS IN MICE
    LAUDRUP, P
    KLITGAARD, H
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 250 (01) : 15 - 22
  • [26] INTRASTRIATAL INJECTION OF A SELECTIVE METABOTROPIC EXCITATORY AMINO-ACID RECEPTOR AGONIST INDUCES CONTRALATERAL TURNING IN THE RAT
    SACAAN, AI
    MONN, JA
    SCHOEPP, DD
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1991, 259 (03): : 1366 - 1370
  • [27] ACTIVATION OF INTERLEUKIN-2 RECEPTOR GENE BY FORSKOLIN AND CYCLIC-AMP ANALOGS
    NARUMIYA, S
    HIRATA, M
    NANBA, T
    NIKAIDO, T
    TANIGUCHI, Y
    TAGAYA, Y
    OKADA, M
    MITSUYA, H
    YODOI, J
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 143 (02) : 753 - 760
  • [28] INHIBITION BY FORSKOLIN OF EXCITATORY AMINO ACID-INDUCED ACCUMULATION OF CYCLIC-AMP IN GUINEA-PIG HIPPOCAMPAL SLICES
    BABA, A
    NISHIUCHI, Y
    UEMURA, A
    TATSUNO, T
    IWATA, H
    JOURNAL OF NEUROCHEMISTRY, 1988, 51 (01) : 237 - 242
  • [29] EFFECT OF DIFFERENT ALKYLXANTHINES ON ADENOSINE-RECEPTOR MEDIATED INHIBITION OF FAT-CELL CYCLIC-AMP ACCUMULATION
    LINDGREN, E
    FREDHOLM, BB
    ACTA PHARMACOLOGICA ET TOXICOLOGICA, 1981, 49 : 29 - 29
  • [30] EFFECT OF ADENOSINE RECEPTOR AGONISTS AND OTHER COMPOUNDS ON CYCLIC-AMP ACCUMULATION IN FORSKOLIN-TREATED HIPPOCAMPAL SLICES
    FREDHOLM, BB
    JONZON, B
    LINDSTROM, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 332 (02) : 173 - 178