GENERALIZED SEIZURES IN RENAL-TRANSPLANT RECIPIENTS

We describe two renal transplant recipients treated with CsA who developed generalized seizures. There was no previous history of convulsions and investigation did not show any other common cause except hypomagnesaemia in one. During follow up the convulsions did not recur even after withdrawal of phenytoin. Cyclosporin has been linked with wide spectrum of neurological side effects and several factors been proposed as predisposing but the precise mechanism remains undetermined. There was no relationship between CsA blood levels and convulsions but it seems indicated to stop the drug or reduce dosage temporarily if convulsions occur. This side effect must be borne in mind in all patients treated with CsA.