Introduction: Acute appendicitis (AA), remains the most common indication for emergency abdominal surgery with a lifetime incidence of 7%. Although AA can occur at any age, onset of infection is most common between the ages of 10 and 20 years. AA is more common in males, with a reported male to female ratio of 1.4: 1. Objectives of the study: The basic aim of the study is to analyze the Platelet count and its diagnostic parameters of surgery in Acute Appendicitis. Methodology of the study: This study was conducted at Nishtar medical college Multan and Mayo hospital Lahore during March 2018 to July 2018. We retrospectively reviewed the medical records of 241 patients who had undergone appendectomy in the General Surgery Unit. The primary analysis in this study was the comparison of the patient MPV and LC values that at the time of AA to data collected prior to the operation. Results: Diagnostically, the sensitivity, specificity and diagnostic accuracy were 73.1%, 94.0%, and 78% for white blood cell count, 70.0%, 96.0%, and 76.0% for neutrophil percentage, 29.5%, 49.0%, and 34.0% for mean platelet volume, and 97.1%, 93.0%, and 96.0% for platelet distribution width, respectively. Conclusion: Acute appendicitis is the most common indication for emergent abdominal surgery and remains difficult to diagnose. The current study indicates that mean platelet volume is decreased in acute appendicitis.