Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs

被引：6

作者：

Hayun ^{[1
]}

Hudiyono, Sumi ^{[2
]}

Hanafi, Muhammad ^{[3
]}

Yanuar, Arry ^{[1
]}

机构：

[1] Univ Indonesia, Fac Pharm, Depok 16424, West Java, Indonesia

[2] Univ Indonesia, Fac Nat Sci, Dept Chem, Depok 16424, West Java, Indonesia

[3] Indonesian Inst Sci, Res Ctr Chem, Serpong 15314, West Java, Indonesia

来源：

PHARMACEUTICALS | 2012年 / 5卷 / 12期

关键词：

quinazolin-4-one; benzenesulfonamide; COX-2; inhibitor;

D O I：

10.3390/ph5121282

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed on the basis of FT-IR, H-1-NMR, C-13-NMR and mass spectral data. The COX-2 inhibition screening assay revealed that 4-[(E)-2-{3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl}ethenyl]benzene-1-sulfonamide had a maximum COX-2 inhibition (47.1%), at a concentration of 20 mu M.

引用

页码：1282 / 1290

页数：9

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