SIGNIFICANCE OF ELEVATED URINARY HUMAN INTESTINAL ALKALINE-PHOSPHATASE IN JAPANESE PEOPLE EXPOSED TO ENVIRONMENTAL CADMIUM

Urinary human intestinal alkaline phosphatase (IAP),beta(2)-microglobulin (beta(2)-MG) and N-acetyI-beta-D-glucosaminidase (NAG) were analyzed in 40 Japanese environmental-cadmium (Cd)-exposed and 40 non-exposed subjects to evaluate early biological markers for Cd-induced renal damage, All urinary indicators were significantly higher in the Cd-exposed subjects than non-exposed subjects. A fourth-order function was fitted far the relationship between beta(2)-MG and IAP or NAG. The beta(2)-MG concentration corresponding to the inflexion point for IAP was smaller than that for NAG. This result may support the contention that the cells containing IAP are damaged earlier than those containing NAG, and that IAP is a useful marker for detecting renal tubular dysfunction in people moderately exposed to Cd. However, in the stage of severe renal damage, the combination of IAP and beta(2)-MG is considered to be more useful.