A NEW SYNTHESIS OF 5-BROMOAPLYSINOPSIN, 6-BROMOAPLYSINOPSIN AND 3'-DEMETHYLAPLYSINOPSIN AND THEIR BIOLOGICAL-ACTIVITIES

被引：0
|
作者：
GULATI, D [1 ]
CHAUHAN, PMS [1 ]
PRATAP, R [1 ]
BHAKUNI, DS [1 ]
机构：
[1] CENT DRUG RES INST,DIV MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1994年 / 33卷 / 01期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthesis of 5-bromoaplysinopsin (11), 6-bromoaplysinopsin (15) and 3-demethylaplysinopsin (24) has been developed. A number of their analogues have been synthesized and evaluated for biological activities. Of the compounds tested, compounds 5,7-9 are active against the fungus Sporotrichum schenckii, 6, 8, and 11 active against Trichophyton mentagrophytes and 8 against Cryptococcus neoformans. Compound 8 also exhibits moderate antiviral activity. Compounds 2, 8 and 9 show significant in vitroactivity against Leishmania donovanti a dose of 100 mug/ml.
引用
收藏
页码：10 / 16
页数：7
相关论文
共 50 条
  • [1] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME NEW ARYLAZOPYRAZOLES
    JOLLY, VS
    PATHAK, M
    JAIN, R
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (04): : 505 - 507
  • [2] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 6-AZAPROSTACYCLIN DERIVATIVES
    MIYAJIMA, K
    TAKEMOTO, M
    ACHIWA, K
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S143 - S143
  • [3] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME NEW PYRIDAZINE DERIVATIVES
    SEADA, M
    FAWZY, MM
    JAHINE, H
    ABDELMEGID, M
    SAAD, RR
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1989, 36 (03) : 241 - 249
  • [4] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME NEW 5'-SUBSTITUTED S-ADENOSYLHOMOCYSTEINE ANALOGS
    SHIRE, D
    BLANCHARD, P
    RAIES, A
    LAWRENCE, F
    ROBERTGERO, M
    LEDERER, E
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1983, 2 (01): : 21 - 31
  • [5] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF A PHOSPHORODITHIOATE ANALOG OF 2',5'-OLIGOADENYLATE
    BEIGELMAN, L
    MATULICADAMIC, J
    HAEBERLI, P
    USMAN, N
    DONG, BH
    SILVERMAN, RH
    KHAMNEI, S
    TORRENCE, PF
    NUCLEIC ACIDS RESEARCH, 1995, 23 (19) : 3989 - 3994
  • [6] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 5'-MONO, DI AND TRIPHOSPHATES OF SOME 6-SUBSTITUTED ADENOSINES
    DE, NC
    CHEN, CM
    MITTELMAN, A
    CHHEDA, GB
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1976, 172 (SEP3): : 119 - 119
  • [7] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME NEW ACID HYDRAZIDES AND THEIR DERIVATIVES
    JOLLY, VS
    JAIN, R
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1992, 69 (01) : 43 - 45
  • [8] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF NEW FLUORINATED ABSCISIC-ACID
    KIM, BT
    MIN, YK
    ASAMI, T
    PARK, NK
    JEONG, IH
    CHO, KY
    YOSHIDA, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (03) : 275 - 278
  • [9] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF METABOLITES OF MOSAPRIDE, A NEW GASTROPROKINETIC AGENT
    KATO, S
    MORIE, T
    YOSHIDA, N
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (04) : 699 - 702
  • [10] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME NEW PEPTIDE SUBSTITUTED CARBAZOLOQUINONES
    HAMMAM, AS
    RAHMAN, AEA
    ELMAGHRABY, MA
    MOHAMED, FK
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1982, 21 (04): : 348 - 351
12345