SYNTHESIS OF A POTENT AND SELECTIVE NONPEPTIDE CCK-B GASTRIN RECEPTOR ANTAGONIST TRITIATED LIGAND

被引：10

作者：

HILL, D ^{[1
]}

HORWELL, DC ^{[1
]}

HUNTER, JC ^{[1
]}

KNEEN, CO ^{[1
]}

PRITCHARD, MC ^{[1
]}

SUMANCHAUHAN, N ^{[1
]}

机构：

[1] PARKE DAVIS & CO,NEUROSCI RES CTR,ADDENBROOKES HOSP SITE,HILLS RD,CAMBRIDGE CB2 2QB,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80686-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a novel, potent and selective non-peptide gastrin/CCK-B receptor antagonist in a tritiated form is described, via a route which allows for introduction of the radiolabel in the final step.

引用

页码：885 / 888

页数：4

共 50 条

[1] DEVELOPMENT OF SELECTIVE NONPEPTIDE CCK-A AND CCK-B GASTRIN RECEPTOR ANTAGONISTS
FREIDINGER, RM
BOCK, MG
DIPARDO, RM
EVANS, BE
RITTLE, KE
WHITTER, WL
VEBER, DF
ANDERSON, PS
CHANG, RSL
LOTTI, VJ
NEUROPEPTIDE CHOLECYSTOKININ ( CCK ): ANATOMY AND BIOCHEMISTRY, RECEPTORS, PHARMACOLOGY AND PHYSIOLOGY, 1989, : 123 - 132
[2] Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509
Hagishita, S
Murakami, Y
Seno, K
Kamata, S
Haga, N
Konoike, T
Kanda, Y
Kiyama, R
Shiota, T
Ishihara, Y
Ishikawa, M
Shimamura, M
Abe, K
Yoshimura, K
BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (08) : 1695 - 1714
[3] THE CCK-B/GASTRIN RECEPTOR - IDENTIFICATION OF AMINO-ACIDS THAT DETERMINE NONPEPTIDE ANTAGONIST AFFINITY
KOPIN, AS
BEINBORN, M
LEE, YM
MCBRIDE, EW
QUINN, SM
CHOLECYSTOKININ, 1994, 713 : 67 - 78
[4] SYNTHESIS AND CCK-B BINDING AFFINITIES OF CYCLIC ANALOGS OF THE POTENT AND SELECTIVE CCK-B RECEPTOR ANTAGONIST CIL-988
DIDIER, E
HORWELL, DC
PRITCHARD, MC
TETRAHEDRON, 1992, 48 (39) : 8471 - 8490
[5] RATIONALLY DESIGNED DIPEPTOID ANALOGS OF CCK - ACID MIMICS OF THE POTENT AND SELECTIVE NONPEPTIDE CCK-B RECEPTOR ANTAGONIST CI-988
DRYSDALE, MJ
PRITCHARD, MC
HORWELL, DC
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (14) : 2573 - 2581
[6] A NEW POTENT AND SELECTIVE NON-PEPTIDE GASTRIN ANTAGONIST AND BRAIN CHOLECYSTOKININ RECEPTOR (CCK-B) LIGAND - L-365,260
LOTTI, VJ
CHANG, RSL
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 162 (02) : 273 - 280
[7] An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist (+)-AG-041R
Sato, Shigeki
Shibuya, Masatoshi
Kanoh, Naoki
Iwabuchi, Yoshiharu
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (19): : 7522 - 7524
[8] Is the truncated CCK-B/gastrin receptor (ΔCCK-B) the autocrine gastrin receptor in human colorectal tumours?
McWilliams, DF
Seth, R
Michaeli, D
Watson, SA
GASTROENTEROLOGY, 2000, 118 (04) : A307 - A307
[9] Design and synthesis of novel nonpeptide CCK-B receptor antagonists
Padia, JK
Chilvers, H
Daum, P
Pinnock, R
SumanChauhan, N
Webdale, L
Trivedi, BK
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (07) : 805 - 810
[10] THE UREIDOACETAMIDES, A NOVEL FAMILY OF NONPEPTIDE CCK-B/GASTRIN ANTAGONISTS
BOHME, GA
BERTRAND, P
GUYON, C
CAPET, M
PENDLEY, C
STUTZMANN, JM
DOBLE, A
DUBROEUCQ, MC
MARTIN, G
BLANCHARD, JC
CHOLECYSTOKININ, 1994, 713 : 118 - 120

← 1 2 3 4 5 →