REGIONAL VARIATIONS IN TOTAL AND NONPROTEIN SULFHYDRYL COMPOUNDS IN THE HUMAN GASTRIC-MUCOSA AND EFFECTS OF ETHANOL

被引:22
|
作者
LOGUERCIO, C
ROMANO, M
DISAPIO, M
NARDI, G
TARANTO, D
GRELLA, A
BLANCO, CD
机构
[1] STAZ ZOOL ANTON DOHRN, BIOCHEM LAB, I-80138 NAPLES, ITALY
[2] NAPLES UNIV, SCH MED 1, DEPT DIGEST PHYSIOPATHOL, I-80138 NAPLES, ITALY
[3] NAPLES UNIV, SCH MED 1, DEPT EMERGENCY TOXICOL, NAPLES, ITALY
关键词
CYSTEINE; ETHANOL; GLUTATHIONE; HUMAN GASTRIC MUCOSA; SULFHYDRYL;
D O I
10.3109/00365529109003954
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This study evaluated the regional distribution of sulfhydryl compounds in the human gastric mucosa and the effect of ethanol on gastric sulfhydryl tissue levels. Total sulfhydryl, glutathione, and cysteine and their oxidized forms were measured in biopsy specimens taken from the gastric body and antrum of 22 healthy volunteers. Total sulfhydryl and glutathione contents of the body of the stomach were significantly higher than those of the antrum. In contrast, cysteine concentration was higher in the gastric antrum than in the body. No difference was found in the levels of oxidized sulfhydryls between the gastric body and antrum. The effect of acute administration of ethanol on gastric sulfhydryl content was studied in nine subjects. Ethanol caused gross mucosal damage and lowered the concentration of sulfhydryl compounds in both the body and the antrum. In 10 chronic alcoholics total sulfhydryl and glutathione, but not cysteine, were markedly decreased in the gastric body but not in the antrum as compared with nonalcoholic controls. In conclusion, 1) the human gastric body contains significantly higher tissue levels of total sulfhydryls and glutathione and lower concentrations of cysteine than the antrum; 2) ethanol in a damaging concentration significantly decreases gastric tissue levels of sulfhydryl compounds; and 3) chronic ethanol intake lowers total sulfhydryl and glutathione tissue levels in the gastric body.
引用
收藏
页码:1042 / 1048
页数:7
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