CHRONIC ETHANOL TREATMENT - EFFECTS ON THE ACTIVATION OF BRAIN BETA-ENDORPHIN SYSTEM BY NOVELTY

被引：0
|
作者：
DALMAZ, C
NETTO, CBO
NETTO, CBO
FIN, CA
IZQUIERDO, I
机构：
来源：
PSYCHOBIOLOGY | 1991年 / 19卷 / 01期
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暂无
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Chronic ethanol ingestion in rats abolishes novelty-induced antinociception, as measured by a tailflick method. This treatment also inhibited the posttraining facilitatory effect of naloxone and the posttraining amnesic effect of beta-endorphin in a step-down inhibitory avoidance task. Measurement of hypothalamic beta-endorphin-like immunoreactivity (beta-EPLIR) shows that there is a decrease in the levels of this peptide in chronic ethanol-treated rats. Exposure to a novel situation, which causes a decrease of beta-EPLIR in control (water-treated) rats, had no effect in ethanol-treated rats. Taken together, these results suggest that chronic ethanol treatment decreases hypothalamic beta-endorphin levels and makes this system unresponsive to novelty.
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页码：70 / 74
页数：5
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