HUMAN PAPILLOMAVIRUS TYPE-RELATED DNA AND C-MYC ONCOGENE ALTERATIONS IN COLON CANCER CELL-LINES

被引：17

作者：

CHENG, JY ^{[1
]}

MENG, CL ^{[1
]}

CHAO, CF ^{[1
]}

GAU, SD ^{[1
]}

LIN, JC ^{[1
]}

机构：

[1] NATL DEF MED CTR, TRI SERV GEN HOSP, DEPT MED RES, TAIPEI, TAIWAN

来源：

DISEASES OF THE COLON & RECTUM | 1991年 / 34卷 / 06期

关键词：

HPV; C-MYC; COLON CANCER;

D O I：

10.1007/BF02049931

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although squamous-cell eqithelium is the most frequent target site of human papillomavirus (HPV) infection, a similar infection is demonstrated in columnar epithelial cells in this paper. The papillomavirus expression in three cell lines was detected in colorectal adenocarcinoma of Chinese patients. The HPV-16 and HPV-18 DNA sequences were found in colorectal cancer cell lines, which might suggest the correlation of HPV to the etiology of colorectal cancers. In addition, c-myc oncogene was identified by amplification in all three colorectal cancer cell lines, but only normal germ-line fragments were found in control tissue. The correlation between HPV and c-myc, and the implications of these findings in colorectal cancers are also discussed.

引用

页码：469 / 474

页数：6

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