lmmunohistochemical expression of p16 in Carcinoma Ex-pleomorphic Adenoma (undifferentiated and Adenocarcinoma Types)

被引：5
|
作者：
Tarakji, Bassel [1 ]
Altamimi, Monammed Alsakran [2 ]
Baroudi, Kusai [2 ]
Nassain, Mohammad Z. [2 ]
Qalenzi, Faris [3 ]
机构：
[1] Alfarabi Coll Dent & Nursing, Dept Oral Maxillofacial Surg, Riyadh, Saudi Arabia
[2] Alfarabi Coll Dent & Nursing, Dept Restorat Dent Sci, Riyadh, Saudi Arabia
[3] Prince Salman Univ, Coll Appl Med Sci, Al Kharj, Saudi Arabia
来源：
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2013年 / 7卷 / 12期
关键词：
p16; expression; CDKN2; gene;
D O I：
10.7860/JCDR/2013/7380.3851
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma expleonnorphic adenomas. Study Design: A selected series of 27 cases of carcinoma expleonnorphic adenomas were examined. Results: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma expleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining. Conclusion: This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
引用
收藏
页码：3054 / 3056
页数：3
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