DETERMINATION OF FLUOROQUINOLONE ANTIBACTERIALS AS N-ACYL DERIVATIVES

被引：10
|
作者：
MORLEY, JA
ELROD, L
机构：
[1] Physical Analytical Chemistry Department, Abbott Laboratories, North Chicago, 60064-4000, Illinois
来源：
CHROMATOGRAPHIA | 1993年 / 37卷 / 5-6期
关键词：
COLUMN LIQUID CHROMATOGRAPHY; FLUOROQUINOLONES; N-ACYL DERIVATIVES OF FLUOROQUINOLONES; RETENTION VS STRUCTURE;
D O I：
10.1007/BF02278637
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and quantitative method for the preparation and high performance liquid chromatography (HPLC) of N-acylated fluoroquinolones has been developed. The acylation procedure was performed with four different acid anhydrides and found to be applicable to several fluoroquinolones. The acylated derivatives were chromatographed directly on a Nucleosil C18 column without the necessity of further sample manipulation. Detector response for the N-acetyl derivatives of norfloxacin, ciprofloxacin, sarafloxacin, and temafloxacin was linear to at least 50 mug/mL. The retention behavior of the N-acyl derivatives can be predicted by the length of the carbon chain of the amide.
引用
收藏
页码：295 / 299
页数：5
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