DECREASE IN MESSENGER-RNA LEVELS BUT NOT IN THE DENSITY OF D2 DOPAMINE-RECEPTORS IN RAT STRIATUM AFTER TRANSIENT FOREBRAIN ISCHEMIA

被引：17

作者：

BENFENATI, F ^{[1
]}

CIMINO, M ^{[1
]}

ZOLI, M ^{[1
]}

GRIMALDI, R ^{[1
]}

ZINI, I ^{[1
]}

AGNATI, LF ^{[1
]}

机构：

[1] UNIV URBINO,INST PHARMACOL & PHARMACOGNOSY,I-61029 URBINO,ITALY

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 01期

关键词：

TRANSIENT FOREBRAIN ISCHEMIA; STRIATUM; DOPAMINE RECEPTOR; D2 RECEPTOR MESSENGER RNA; INSITU HYBRIDIZATION; AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(91)90357-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

D2 dopamine receptor mRNA was analyzed by in situ hybridization histochemistry in rat striatum 7 days after transient forebrain ischemia. A patchy disappearance of the D2 receptor mRNA was observed in the dorsolateral striatum. In the same area, a disappearance of D1 binding sites occurred in the absence of significant changes in D2 receptor density. These results suggest that, although D2 receptors seem to be apparently unaffected after forebrain ischemia, a long-lasting impairment of their neosynthesis may be present in striatal D2 dopaminoceptive neurons.

引用

页码：6 / 8

页数：3

共 50 条

[41] CHANGES IN MESSENGER-RNA FOR METABOTROPIC GLUTAMATE RECEPTORS AFTER TRANSIENT CEREBRAL-ISCHEMIA
ROSDAHL, D
SEITZBERG, DA
CHRISTENSEN, T
BALCHEN, T
DIEMER, NH
NEUROREPORT, 1994, 5 (05) : 593 - 596
[42] EVIDENCE FOR THE PRESENCE OF D1 AND D2 DOPAMINE-RECEPTORS IN RAT ESOPHAGUS
SIGALA, S
MISSALE, G
MISSALE, C
MEMO, M
CESTARI, R
SPANO, PF
PHARMACOLOGICAL RESEARCH, 1989, 21 (01) : 123 - 124
[43] FACTORS CONTROLLING RETINAL D1 AND D2 DOPAMINE-RECEPTORS IN THE RAT
PHILLIPSON, OT
PLUMMER, CJ
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 396 : P147 - P147
[44] RAT STRIATAL AND MESENCEPHALIC NEURONS CONTAIN THE LONG ISOFORM OF THE D2 DOPAMINE RECEPTOR MESSENGER-RNA
LEMOINE, C
BLOCH, B
MOLECULAR BRAIN RESEARCH, 1991, 10 (04): : 283 - 289
[45] D2 DOPAMINE-RECEPTORS IN THE RAT PREFRONTAL CORTEX - CHARACTERIZATION AND ALTERATION BY STRESS
MACLENNAN, AJ
PELLEYMOUNTER, MA
ATMADJA, S
JAKUBOVIC, A
MAIER, SF
FIBIGER, HC
BRAIN RESEARCH, 1989, 477 (1-2) : 300 - 307
[46] DIRECT VISUALIZATION AND CELLULAR-LOCALIZATION OF D1 AND D2 DOPAMINE-RECEPTORS IN RAT FOREBRAIN BY USE OF FLUORESCENT LIGANDS
ARIANO, MA
MONSMA, FJ
BARTON, AC
KANG, HC
HAUGLAND, RP
SIBLEY, DR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) : 8570 - 8574
[47] MODULATION OF ACETYLCHOLINE-RELEASE BY D1, D2 DOPAMINE-RECEPTORS IN RAT STRIATUM UNDER FREELY MOVING CONDITIONS
AJIMA, A
YAMAGUCHI, T
KATO, T
BRAIN RESEARCH, 1990, 518 (1-2) : 193 - 198
[48] Melatonin administration increases the affinity of D2 dopamine receptors in the rat striatum
Hamdi, A
LIFE SCIENCES, 1998, 63 (23) : 2115 - 2120
[49] OVARIECTOMY AND SUBCHRONIC ESTRADIOL-17-BETA DECREASE DOPAMINE D1 AND D2 RECEPTORS IN RAT STRIATUM
TONNAER, JADM
LEINDERS, T
VANDELFT, AML
NEUROENDOCRINOLOGY LETTERS, 1988, 10 (04) : 282 - 282
[50] CHARACTERIZATION OF D2 RECEPTORS AND DOPAMINE LEVELS IN THE THALAMUS OF THE RAT
YOUNG, KA
WILCOX, RE
LIFE SCIENCES, 1991, 48 (19) : 1845 - 1852

← 1 2 3 4 5 →