DECREASE IN MESSENGER-RNA LEVELS BUT NOT IN THE DENSITY OF D2 DOPAMINE-RECEPTORS IN RAT STRIATUM AFTER TRANSIENT FOREBRAIN ISCHEMIA

被引：17

作者：

BENFENATI, F ^{[1
]}

CIMINO, M ^{[1
]}

ZOLI, M ^{[1
]}

GRIMALDI, R ^{[1
]}

ZINI, I ^{[1
]}

AGNATI, LF ^{[1
]}

机构：

[1] UNIV URBINO,INST PHARMACOL & PHARMACOGNOSY,I-61029 URBINO,ITALY

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 01期

关键词：

TRANSIENT FOREBRAIN ISCHEMIA; STRIATUM; DOPAMINE RECEPTOR; D2 RECEPTOR MESSENGER RNA; INSITU HYBRIDIZATION; AUTORADIOGRAPHY;

D O I：

10.1016/0304-3940(91)90357-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

D2 dopamine receptor mRNA was analyzed by in situ hybridization histochemistry in rat striatum 7 days after transient forebrain ischemia. A patchy disappearance of the D2 receptor mRNA was observed in the dorsolateral striatum. In the same area, a disappearance of D1 binding sites occurred in the absence of significant changes in D2 receptor density. These results suggest that, although D2 receptors seem to be apparently unaffected after forebrain ischemia, a long-lasting impairment of their neosynthesis may be present in striatal D2 dopaminoceptive neurons.

引用

页码：6 / 8

页数：3

共 50 条

[1] DIFFERENTIAL INFLUENCE OF HALOPERIDOL AND SULPIRIDE ON DOPAMINE-RECEPTORS AND PEPTIDE MESSENGER-RNA LEVELS IN THE RAT STRIATUM AND PITUITARY
JABER, M
TISON, F
FOURNIER, MC
BLOCH, B
MOLECULAR BRAIN RESEARCH, 1994, 23 (1-2): : 14 - 20
[2] AF64A LESIONS OF MOUSE STRIATUM CAUSE ROTATIONAL BEHAVIOR AND A REDUCTION IN D2 DOPAMINE-RECEPTORS AND D2 DOPAMINE RECEPTOR MESSENGER-RNA
ZHOU, LW
ZHANG, SP
CONNELL, TA
WEISS, B
FASEB JOURNAL, 1991, 5 (04): : A879 - A879
[3] D2 DOPAMINE-RECEPTORS IN THE HUMAN RETINA - CLONING OF CDNA AND LOCALIZATION OF MESSENGER-RNA
DEARRY, A
FALARDEAU, P
SHORES, C
CARON, MG
CELLULAR AND MOLECULAR NEUROBIOLOGY, 1991, 11 (05) : 437 - 453
[4] D1 AND D2 DOPAMINE-RECEPTORS IN THE RAT STRIATUM
SZMIGIELSKI, A
ZALEWSKAKASZUBSKA, J
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (04) : 1418 - 1419
[5] ONTOGENIC EXPRESSION OF D2 DOPAMINE RECEPTOR MESSENGER-RNA IN RAT CORPUS STRIATUM
CHEN, JAF
WEISS, B
DEVELOPMENTAL BRAIN RESEARCH, 1991, 63 (1-2): : 95 - 104
[6] IRREVERSIBLE BLOCKADE OF D2 DOPAMINE-RECEPTORS BY FLUPHENAZINE-N-MUSTARD INCREASES GLUTAMIC-ACID DECARBOXYLASE MESSENGER-RNA IN RAT STRIATUM
CHEN, JF
WEISS, B
NEUROSCIENCE LETTERS, 1993, 150 (02) : 215 - 218
[7] INVOLVEMENT OF DOPAMINE D1 AND D2 RECEPTORS IN THE REGULATION OF PROENKEPHALIN MESSENGER-RNA ABUNDANCE IN THE STRIATUM AND ACCUMBENS OF THE RAT-BRAIN
ANGULO, JA
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (03) : 1104 - 1109
[8] IRREVERSIBLE BLOCKADE OF D-2 DOPAMINE-RECEPTORS BY FLUPHENAZINE-N-MUSTARD INCREASES D-2 DOPAMINE-RECEPTOR MESSENGER-RNA AND PROENKEPHALIN MESSENGER-RNA AND DECREASES D-1 DOPAMINE-RECEPTOR MESSENGER-RNA AND MU-OPIOID AND DELTA-OPIOID RECEPTORS IN RAT STRIATUM
CHEN, JF
ALOYO, VJ
QIN, ZH
WEISS, B
NEUROCHEMISTRY INTERNATIONAL, 1994, 25 (04) : 355 - 366
[9] PROENKEPHALIN MESSENGER-RNA LEVELS IN RAT STRIATUM ARE INCREASED AND DECREASED, RESPECTIVELY, BY SELECTIVE D2 AND D1 DOPAMINE RECEPTOR ANTAGONISTS
MORRIS, BJ
HUNT, SP
NEUROSCIENCE LETTERS, 1991, 125 (02) : 201 - 204
[10] UP-REGULATION OF DOPAMINE D2 RECEPTOR MESSENGER-RNA IN RAT STRIATUM BY CHRONIC NEUROLEPTIC TREATMENT
ROGUE, P
HANAUER, A
ZWILLER, J
MALVIYA, AN
VINCENDON, G
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1991, 207 (02): : 165 - 168

← 1 2 3 4 5 →