STRUCTURE-FUNCTION-RELATIONSHIPS OF ENDOTHELINS, SARAFOTOXINS, AND THEIR RECEPTOR SUBTYPES

被引：66
|
作者：
SOKOLOVSKY, M
机构：
[1] Laboratory of Neurochemistry, Department of Biochemistry, The George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv
来源：
JOURNAL OF NEUROCHEMISTRY | 1992年 / 59卷 / 03期
关键词：
STRUCTURE-FUNCTION; BINDING; RECEPTOR(S); DISTRIBUTION; COVALENT LABELING; CLONING;
D O I：
10.1111/j.1471-4159.1992.tb08318.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The endothelins (ETs) and sarafotoxins (SRTXs) are two structurally related families of potent vasoactive peptides. Although their physiological functions have yet to be precisely elucidated, it seems likely that the ETs are involved in pathophysiological conditions such as hypertension and heart failure. In this minireview, recent advances in the biochemical characterization of the ET/SRTX system, with special reference to structure-function relationships and ET/SRTX receptor subtypes, are described, as well as the recent cloning and expression of ET receptors.
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页码：809 / 821
页数：13
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