PACKED-COLUMN DEVELOPMENT IN SUPERCRITICAL FLUID CHROMATOGRAPHY

Having been categorically dismissed as inapplicable for supercritical fluid chromatography during the mid-1980s, packed columns are rapidly regaining much of their lost popularity. Much of the renewed interest stems from the introduction of more deactivated polymer-coated silica particles, which enable the separation of highly polar analytes to be carried out with nonmodified carbon dioxide. Furthermore, the employment of packed capillary columns makes it possible to utilize both GC-like and LC-like detectors. Major findings in the evolution of packed columns, specifically for supercritical fluid chromatography, are discussed. © 1990 Oxford University Press.