DELTA-OPIOID RECEPTOR-BINDING SITES IN RODENT SPINAL-CORD

被引：16

作者：

TRAYNOR, JR ^{[1
]}

HUNTER, JC ^{[1
]}

RODRIGUEZ, RE ^{[1
]}

HILL, RG ^{[1
]}

HUGHES, J ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS RES UNIT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 100卷 / 02期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb15802.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The δ-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin showed an antinociceptive effect in the mouse tail-flick test, following intrathecal administration. This action was reversed by naloxone and by the selective δ-opioid receptor antagonist ICI 174864. High affinity, saturable binding of [3H]-[D-Pen2,D-Pen5]enkephalin has been demonstrated in spinal cord homogenates from guinea-pig, hamster, rat and both adult and young (18-20 g) mice. The binding was shown by autoradiography to be concentrated in the superficial laminae of the dorsal horn. Competition studies confirmed that the binding of [3H]-[D-Pen2,D-Pen5]enkephalin was to the δ-opioid site. However, anomalies were seen with displacement assays using μ-ligands, which may suggest some common high affinity site for δ- and μ-opioid receptor agonists in the spinal cord. The results add further evidence for a role of the δ-opioid receptor in spinally-mediated antinociception.

引用

页码：319 / 323

页数：5

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