INVITRO BRAIN ACETYLCHOLINESTERASE RESPONSE AMONG 3 INBRED STRAINS OF MICE TO MONOCROTOPHOS

被引：6
|
作者：
RAO, JV
SWAMY, AN
YAMIN, S
机构：
[1] Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad
来源：
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1991年 / 26卷 / 04期
关键词：
ACETYLCHOLINESTERASE; MICE; MONOCROTOPHOS;
D O I：
10.1080/03601239109372748
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The strain differences in the neurotoxic potential of monocrotophos (MCP) were assessed by determining the inhibition of brain acetylcholinesterase (AChE) in BALB/cAnN, DBA/2J and C57BL/6J in vitro. MCP being a competitive inhibitor for AChE, alters the Km values widely among these inbred strains. Comparatively least alterations in Km were found in BALB/cAnN and maximum in DBA/2J. Based on the Ki values DBA/2J was found to be the most sensitive strain to MCP inhibition followed by C57BL/6J and BALB/cAnN.
引用
收藏
页码：449 / 458
页数：10
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