SYNTHESIS AND 5-HT3 RECEPTOR AGONIST ACTIVITY OF ARYLUREAS DERIVED FROM HISTAMINE

被引：5

作者：

BERMUDEZ, J ^{[1
]}

BOYLAND, P ^{[1
]}

KING, FD ^{[1
]}

SUMMERSELL, RJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,COLDHARBOUR RD,HARLOW,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80877-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of aryl ureas derived from histamine is described. The compounds are shown to be 5-HT3 receptor agonists by their ability to initiate the Bezold-Jarisch reflux and to displace [H-3]-BRL 43694 from central 5-HT3 receptors with a potency equivalent to that of 5-HT.

引用

页码：205 / 208

页数：4

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