ACTIVATED ASTROCYTES OF THE MOUSE HIPPOCAMPUS CONTAIN HIGH-LEVELS OF NADPH-DIAPHORASE

被引：85

作者：

WALLACE, MN ^{[1
]}

FREDENS, K ^{[1
]}

机构：

[1] AARHUS UNIV,INST NEUROBIOL,DK-8000 AARHUS,DENMARK

来源：

NEUROREPORT | 1992年 / 3卷 / 11期

基金：

英国惠康基金;

关键词：

ACTIVATED GLIA; NITRIC OXIDE SYNTHASE; KAINIC ACID; MOUSE HIPPOCAMPUS;

D O I：

10.1097/00001756-199211000-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NADPH-DIAPHORASE has recently been shown to be identical to nitric oxide synthase in brain neurones. In the intact brain, NADPH-diaphorase is only present in selected populations of neurones and is not detectable in glia. However following a lesion in the mouse retrosplenial cortex, activated astrocytes display intense NADPH-diaphorase activity throughout their cytoplasm. After a control saline injection, NADPH-diaphorase-positive activated glia are only observed in damaged tissue immediately surrounding the injection site, but when kainic acid is injected unilaterally, activated astrocytes occur in the hippocampal formation bilaterally. This indicates that astrocytes activated by intense neuronal activity, as well as by direct mechanical damage, express high levels of NADPH-diaphorase.

引用

页码：953 / 956

页数：4

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