A HIGHLY POTENT, ORALLY-ACTIVE IMIDAZO[4,5-B]PYRIDINE BIPHENYLACYLSULFONAMIDE (MK-996-L-159,282) - A NEW ANGIOTENSIN-II RECEPTOR ANTAGONIST

被引:58
|
作者
CHAKRAVARTY, PK
NAYLOR, EM
CHEN, A
CHANG, RSL
CHEN, TB
FAUST, KA
LOTTI, VJ
KIVLIGHN, SD
GABLE, RA
ZINGARO, GJ
SCHORN, TW
SCHAFFER, LW
BROTEN, TP
SIEGL, PKS
PATCHETT, AA
GREENLEE, WJ
机构
[1] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,DEPT PHARMACOL,W POINT,PA 19486
关键词
D O I
10.1021/jm00050a002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4068 / 4072
页数:5
相关论文
共 22 条
  • [1] POTENT, ORALLY ACTIVE IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    MANTLO, NB
    CHAKRAVARTY, PK
    ONDEYKA, D
    CHEN, A
    CAMARA, VJ
    CHANG, RSL
    LOTTI, VJ
    SIEGL, PKS
    PATCHETT, AA
    GREENLEE, WJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 71 - MEDI
  • [2] POTENT, ORALLY ACTIVE IMIDAZO[4,5-B]PYRIDINE-BASED ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    MANTLO, NB
    CHAKRAVARTY, PK
    ONDEYKA, DL
    SIEGL, PKS
    CHANG, RS
    LOTTI, VJ
    FAUST, KA
    CHEN, TB
    SCHORN, TW
    SWEET, CS
    EMMERT, SE
    PATCHETT, AA
    GREENLEE, WJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) : 2919 - 2922
  • [3] NEW PROCESS FOR THE SYNTHESIS OF IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS POTENT ORALLY-ACTIVE THROMBOXANE-A2 RECEPTOR ANTAGONISTS
    NICOLAI, E
    CLAUDE, S
    TEULON, JM
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (01) : 73 - 75
  • [4] IN-VIVO PHARMACOLOGY AND ANTIHYPERTENSIVE ACTIVITY OF L-159,282 (MK-996) A NONPEPTIDE ANGIOTENSIN-II (A-II) RECEPTOR ANTAGONIST
    SIEGL, PKS
    GABEL, RA
    ZINGARO, GJ
    SCHORN, T
    HARVEY, C
    ARBEGAST, P
    BROTEN, TP
    SCHAFFER, LW
    CHAKRAVARTY, PK
    GREENLEE, W
    NAVLOR, E
    PATCHETT, AA
    KIVLIGHN, SD
    FASEB JOURNAL, 1994, 8 (05): : A881 - A881
  • [5] PHARMACOLOGY OF LR-B/081, A NEW HIGHLY POTENT, SELECTIVE AND ORALLY-ACTIVE, NONPEPTIDE ANGIOTENSIN-II AT(1) RECEPTOR ANTAGONIST
    CIRILLO, R
    RENZETTI, AR
    CUCCHI, P
    GUELFI, M
    SALIMBENI, A
    CALIARI, S
    CASTELLUCCI, A
    EVANGELISTA, S
    SUBISSI, A
    GIACHETTI, A
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (06) : 1117 - 1124
  • [6] SYNTHESIS OF NEW IMIDAZO[1,2-B]PYRIDAZINE ISOSTERES OF POTENT IMIDAZO[4,5-B]PYRIDINE ANGIOTENSIN-II ANTAGONISTS
    WALSH, TF
    FITCH, KJ
    MACCOSS, M
    CHANG, RSL
    KIVLIGHN, SD
    LOTTI, VJ
    SIEGL, PKS
    PATCHETT, AA
    GREENLEE, WJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (01) : 219 - 222
  • [7] IMIDAZO[4,5-B]PYRIDINE-BASED AT(1)/AT(2) ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    MANTLO, NB
    KIM, D
    ONDEYKA, D
    CHANG, RSL
    KIVLIGHN, SD
    SIEGL, PKS
    GREENLEE, WJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (01) : 17 - 22
  • [8] A HIGHLY EFFICIENT SYNTHESIS OF RWJ-47639 - A NOVEL, ORALLY-ACTIVE ANGIOTENSIN-II RECEPTOR ANTAGONIST
    HSI, JD
    MURRAY, WV
    GILL, A
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (08) : 1523 - 1526
  • [9] PHARMACOLOGICAL PROFILE OF VALSARTAN - A POTENT, ORALLY-ACTIVE, NONPEPTIDE ANTAGONIST OF THE ANGIOTENSIN-II AT1-RECEPTOR SUBTYPE
    CRISCIONE, L
    DEGASPARO, M
    BUHLMAYER, P
    WHITEBREAD, S
    RAMJOUE, HPR
    WOOD, J
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (02) : 761 - 771
  • [10] IN-VITRO PHARMACOLOGY OF MK-996, A NEW POTENT AND SELECTIVE ANGIOTENSIN-II (AT(1)) RECEPTOR ANTAGONIST
    CHANG, RSL
    BENDESKY, RJ
    CHEN, TB
    FAUST, KA
    KLING, PJ
    OMALLEY, SA
    NAYLOR, EM
    CHAKRAVARTY, PK
    PATCHETT, AA
    GREENLEE, WJ
    CLINESCHMIDT, BV
    LOTTI, VJ
    DRUG DEVELOPMENT RESEARCH, 1994, 32 (03) : 161 - 171